当两个天主教女孩Catherine和Rebecca在卖宗教用品时候，敲了不该敲的门，事情开始变得恐怖起来......

Catherine and Rebecca are two Catholic school girls going door-to-door selling religious paraphernalia in order to pay for their books and education. Things go horribly wrong when they knock on the wrong door in the wrong neighborhood. "Run! Bitch Run!" is a throwback to the classic rape and revenge films like The Last House on the Left (1972) and Ms .45 (1981).